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ELN-441958
SKU
HY-15043-10 mg
Category Reference compound
Tags Bradykinin Receptor, Endocrinology; Inflammation/Immunology, GPCR/G Protein
$280 – $1,440
Products Details
Product Description
– ELN-441958 is a potent, neutral, competitive and selective bradykinin B1 receptor antagonist with a Ki of 0.26 nM against native human bradykinin B1 receptor. ELN-441958 has high oral bioavailability, and has low CNS exposure in the mouse[1].
Web ID
– HY-15043
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C29H29ClN4O2
References
– [1]Hawkinson JE, et al. Pharmacological, pharmacokinetic, and primate analgesic efficacy profile of the novel bradykinin B1 Receptor antagonist ELN441958. J Pharmacol Exp Ther.2007 Aug;322(2):619-630.
CAS Number
– 913064-47-8
Molecular Weight
– 501.02
Compound Purity
– 99.51
SMILES
– ClC1=C2C(CN(C3=CC=CC(C(N4CCC5(CCN(C6=CC=NC=C6)CC5)CC4)=O)=C3)C2=O)=CC=C1
Clinical Information
– No Development Reported
Research Area
– Endocrinology; Inflammation/Immunology
Solubility
– DMSO : 100 mg/mL (ultrasonic)
Target
– Bradykinin Receptor
Isoform
– Bradykinin B1 Receptor (B1R)
Pathway
– GPCR/G Protein
Product type
– Reference compound
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