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Doxycycline
Price range: 48 CAD through 410 CAD
Products Details
Product Description
– Doxycycline (Doxiciclina) belongs to the tetracycline class of antibiotics and is a broad-spectrum metalloproteinase (MMP) inhibitor with oral activity. Doxycycline has antibacterial activity and antitumor activity.
Web ID
– T1687
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C22H24N2O8
Citations
– 1. Tan Y, Chen X, Xu Z, et al.The mechanics of tumor cells dictate malignancy via cytoskeleton-mediated APC/Wnt/β-catenin signaling.Research.2023
2. Li Y M, Mei Y C, Liu A H, et al.Gcn5-and Bre1-mediated Set2 degradation promotes chronological aging of Saccharomyces cerevisiae.Cell Reports.2023, 42(10).
3. Wang W, Wang M, Du T, et al.SHMT2 Promotes Gastric Cancer Development through Regulation of HIF1α/VEGF/STAT3 Signaling.International Journal of Molecular Sciences.2023, 24(8): 7150.
4. Lu J, Lu Z, Liu L, et al. Identification of crocin as a new hIAPP amyloid inhibitor via a simple yet highly biospecific screening system. Chemistry & Biodiversity. 2021
5. Xin Y, Chen X, Tang X, et al. Mechanics and actomyosin-dependent survival and chemoresistance of suspended tumor cells in shear flow. Biophysical Journal. 2019 May 21;116(10):1803-1814
6. Li Y, Qiao K, Zhang X, et al. Targeting myeloid-derived suppressor cells to attenuate vasculogenic mimicry and synergistically enhance the anti-tumor effect of PD-1 inhibitor. Iscience. 2021, 24(12): 103392.
7. Chen X, Fan Y, Sun J, et al. Nanoparticle-mediated specific elimination of soft cancer stem cells by targeting low cell stiffness. Acta Biomaterialia. 2021
8. Han L, Jiang Y, Shi M, et al.LIPH contributes to glycolytic phenotype in pancreatic ductal adenocarcinoma by activating LPA/LPAR axis and maintaining ALDOA stability.Journal of Translational Medicine.2023, 21(1): 1-21.
9. Hu Z, Lu Y, Cao J, et al.N-acetyltransferase NAT10 controls cell fates via connecting mRNA cytidine acetylation to chromatin signaling.Science Advances.2024, 10(2): eadh9871.
10. Wang J, Zhang B, Chen X, et al.Cell mechanics regulate the migration and invasion of hepatocellular carcinoma cells via JNK signaling.Acta Biomaterialia.2024
References
– Qin Y, et al. Doxycycline reverses epithelial-to-mesenchymal transition and suppresses the proliferation and metastasis of lung cancer cells. Oncotarget. 2015 Dec 1;6(38):40667-79.
CAS Number
– 564-25-0
Molecular Weight
– C22H24N2O8
Compound Purity
– 0.9988
SMILES
– [H][C@@]12[C@@H](C)c3cccc(O)c3C(=O)C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@]1([H])[C@H]2O
Target
– Endogenous Metabolite
Pathway
– Microbiology/Virology|||Proteases/Proteasome
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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