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Doxepin (Hydrochloride)
$50 – $192
Products Details
Product Description
– Doxepin hydrochloride is an orally active tricyclic antidepressant agent. Doxepin hydrochloride is a potent and selective histamine receptor H1 antagonist. Doxepin hydrochloride is also a potent CYP450 inhibitor and significantly inhibits CYP450 2C19 and 1A2[1][2]. Doxepin inhibits reuptake of serotonin and norepinephrine as a tricyclic antidepressant[3].. Doxepin has therapeutic effects in atopic dermatitis，chronic urticarial，can improve cognitive processes， protect central nervous system[4].. Doxepin has also been proposed as a protective factor against oxidative stress[5]..
Web ID
– HY-B0725
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C19H22ClNO
Citations
– Cell Commun Signal. 2023 May 25;21(1):123.|Virus Res. 2022 Aug;317:198816.|J Appl Toxicol. 2023 Apr 14.|Nat Commun. 2022 Nov 10;13(1):6796.
References
– [1]http://pdsp.med.unc.edu/pdsp.php|[2]Hajak, G., et al., Doxepin in the treatment of primary insomnia: a placebo-controlled, double-blind, polysomnographic study. J Clin Psychiatry, 2001. 62(6): p. 453-63.|[3]AnnemiekVermeeren, etal. Effects of the use of hypnotics on cognition. Progress in brain research vol. 190 (2011): 89-103. |[4]G Hajak, etal. Doxepin in the treatment of primary insomnia: a placebo-controlled, double-blind, polysomnographic study. The Journal of clinical psychiatry vol. 62,6 (2001): 453-63.|[5]Mahsa Gharzi, etal. Effects of different doses of doxepin on passive avoidance learning in rats. Advanced biomedical research vol. 2 66. 30 Jul. 2013.|[6]Jimei Bu, etal. Mechanism underlying the effects of doxepin on β-amyloid -induced memory impairment in rats. Iran J Basic Med Sci. 2017 Sep;20(9):1044-1049.
CAS Number
– 1229-29-4
Molecular Weight
– 315.84
Compound Purity
– 99.84
SMILES
– CN(C)CC/C=C1C2=CC=CC=C2OCC3=CC=CC=C/13.Cl
Clinical Information
– Launched
Research Area
– Neurological Disease; Cancer
Solubility
– DMSO : ≥ 100 mg/mL|H2O : ≥ 50 mg/mL
Target
– Cytochrome P450;Histamine Receptor
Isoform
– H1 Receptor
Pathway
– GPCR/G Protein;Immunology/Inflammation;Metabolic Enzyme/Protease;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
