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Diltiazem (hydrochloride)
$55 – $145
Products Details
Product Description
– Diltiazem hydrochloride is a Ca2+ influx inhibitor (slow channel blocker or calcium antagonist).
Web ID
– HY-14656
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C22H27ClN2O4S
Citations
– Pharmacol Res Perspect. 2020 Apr;8(2):e00575.|Virology. 2020 Jan 2;539:38-48.|J Cardiovasc Transl Res. 2023 Jan 30.|Pharmacol Res Perspect. 2021 Oct;9(5):e00879.
References
– [1]Kraus RL, et al. Molecular mechanism of diltiazem interaction with L-type Ca2+ channels. J Biol Chem. 1998 Oct 16;273(42):27205-12.|[2]van Breemen C, et al. The mechanism of inhibitory action of diltiazem on vascular smooth muscle contractility. J Pharmacol Exp Ther. 1981 Aug;218(2):459-63.|[3]Chiesi M, et al. Stereospecific action of diltiazem on the mitochondrial Na-Ca exchange system and on sarcolemmal Ca-channels. Biochem Pharmacol. 1987 Sep 1;36(17):2735-40.|[4]Freitas F, et al. Cardiac microvascular rarefaction in hyperthyroid rats is reversed by losartan, diltiazem, and propranolol. Fundam Clin Pharmacol. 2015 Feb;29(1):31-40.|[5]Sato M, et al. Hypotensive effects of diltiazem hydrochloride in the normotensive, spontaneously hypertensive and renal hypertensive rats (author’s transl). Nihon Yakurigaku Zasshi. 1979 Mar;75(2):99-106.
CAS Number
– 33286-22-5
Molecular Weight
– 450.98
Compound Purity
– 99.83
SMILES
– CN(C)CCN1C2=CC=CC=C2S[C@@H](C3=CC=C(OC)C=C3)[C@@H](OC(C)=O)C1=O.Cl
Clinical Information
– Launched
Research Area
– Cardiovascular Disease; Cancer
Solubility
– H2O : 33.33 mg/mL (ultrasonic)
Target
– Calcium Channel
Isoform
– L-type calcium channel
Pathway
– Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
