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Products Details
Product Description
– Desmethyl-QCA276, the QCA276-based moiety, binds to cereblon ligand via a linker to form PROTAC to degrade BET. QCA276 is a BET inhibitor with an IC50 of 10 nM, and with a Ki of 2.3 nM[1].
Web ID
– T18601
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C21H17N5OS
References
– Qin C, et al. Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression. J Med Chem. 2018 Aug 9;61(15):6685-6704.
CAS Number
– 2126819-55-2
Molecular Weight
– C21H17N5OS
SMILES
– C(#CC=1SC2=C(C1CC=3C=CC=CC3)COCC4=NN=C(N42)C)C=5C=NNC5
Target
– Others
Pathway
– Others
Product type
– PROTAC
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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