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dCBP-1
Price range: 154 CAD through 1,856 CAD
For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.
Products Details
Product Description
– dCBP-1 is a chemical degrader of p300/CBP. dCBP-1 hijacks the E3 ubiquitin ligase CRBN for selective degradation of p300/CBP. Degradation of p300/CBP by dCBP-1 leads to effective multiple myeloma cell killing.
Web ID
– T9370
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C51H63F2N11O10
Citations
– 1. Liu L, Deng P, Liu S, et al.Enhancer remodeling activates NOTCH3 signaling to confer chemoresistance in advanced nasopharyngeal carcinoma.Cell Death & Disease.2023, 14(8): 513.
2. Zhang D, Ma B, Liu D, et al.Discovery of a peptide proteolysis-targeting chimera (PROTAC) drug of p300 for prostate cancer therapy.EBioMedicine.2024, 105.
References
– Raghu Vannam, et al. Targeted degradation of the enhancer lysine acetyltransferases CBP and p300. Cell Chem Biol. 2020 Dec 31;S2451-9456(20)30513-4.
CAS Number
– 2484739-25-3
Molecular Weight
– C51H63F2N11O10
Compound Purity
– 0.9912
SMILES
– C(NC)(=O)N1CC=2C(=NN(C2CC1)C3CCN(C(CCOCCOCCOCCOCCNC=4C=C5C(=CC4)C(=O)N(C5=O)C6C(=O)NC(=O)CC6)=O)CC3)N7C=8C(=CC(=C(C(F)F)C8)C9=CN(C)N=C9)CCC7
Pathway
– Chromatin/Epigenetic|||PROTAC
Product type
– PROTAC
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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