– Dargistotug (M-6223) is a fully human IgG1 monoclonal antibody that targets TIGIT (T cell immune receptor with Ig domain and ITIM), an inhibitory immune checkpoint that depletes NK cells and reduces cytokine secretion via interaction with CD155. It also modulates effector T cell activity and enhances regulatory T cell (Tregs) function, contributing to immunosuppression [1].