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Cutamesine dihydrochloride
$92 – $604
Products Details
Product Description
– Cutamesine dihydrochloride (SA4503 dihydrochloride; AGY94806 dihydrochloride) is a potent Sigma 1 receptor agonist with an IC50 of 17.4 nM in guinea pig brain membranes.
Web ID
– HY-13510
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C23H34Cl2N2O2
References
– [1]Lever JR, et al. Sigma1 and sigma2 receptor binding affinity and selectivity of SA4503 and fluoroethyl SA4503. Synapse. 2006 May;59(6):350-8.|[2]Tuerxun T, et al. SA4503, a sigma-1 receptor agonist, prevents cultured cortical neurons from oxidative stress-induced cell death via suppression of MAPK pathway activation and glutamate receptor expression. Neurosci Lett. 2010 Jan 29;469(3):303-8.
CAS Number
– 165377-44-6
Molecular Weight
– 441.43
Compound Purity
– 98.01
SMILES
– COC1=CC=C(CCN2CCN(CCCC3=CC=CC=C3)CC2)C=C1OC.Cl.Cl
Clinical Information
– Phase 2
Research Area
– Neurological Disease
Solubility
– DMSO : 30 mg/mL (ultrasonic;warming)|H2O : 100 mg/mL (ultrasonic)
Target
– Sigma Receptor
Isoform
– Sigma 1 Receptor
Pathway
– Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
