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CSRM617 hydrochloride
Price range: 56 CAD through 387 CAD
Products Details
Product Description
– CSRM617 hydrochloride is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor), with a Kd of 7.43 µM in SPR assays, directly binding to the OC2-HOX domain. CSRM617 hydrochloride induces apoptosis through the appearance of cleaved Caspase-3 and PARP and is well tolerated in the mouse model of prostate cancer [1].
Web ID
– T10896L
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C10H14ClN3O5
References
– Rotinen M, et, al. ONECUT2 is a targetable master regulator of lethal prostate cancer that suppresses the androgen axis. Nat Med. 2018 Dec;24(12):1887-1898.
CAS Number
– 1353749-74-2
Molecular Weight
– C10H14ClN3O5
Compound Purity
– 0.9947
SMILES
– Cl.NC(CO)C(=O)NN=Cc1ccc(O)c(O)c1O
Target
– Others
Pathway
– Endocrinology/Hormones|||Apoptosis
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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