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Col003
$80 – $700
Products Details
Product Description
– Col003 is a selective and potent inhibitor of Hsp47 and competitively binds to the collagen binding site on Hsp47 (IC50=1.8 μM). Col003 discourages the interaction of Hsp47 with collagen and inhibits collagen secretion by destabilizing the collagen triple helix. Col003 can be used for the investigation of fibrosis[1]
Web ID
– HY-124817
Storage Temperature
– 4°C (Powder, stored under nitrogen)
Shipping
– Room Temperature
Molecular Formula
– C14H11NO4
References
– [1]Ito S, et al. A small-molecule compound inhibits a collagen-specific molecular chaperone and could represent a potential remedy for fibrosis. J Biol Chem. 2017 Dec 8;292(49):20076-20085.
CAS Number
– 328565-16-8
Molecular Weight
– 257.24
Compound Purity
– 99.78
SMILES
– O=CC1=CC(CC2=CC=CC=C2)=CC([N+]([O-])=O)=C1O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– DMSO : 50 mg/mL (ultrasonic)
Target
– HSP
Isoform
– HSP40
Pathway
– Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
