Clozapine N-Oxide

SKU T4494-2 mg Category Small Compound Brand: TargetMol

Price range: 48 CAD through 445 CAD

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Product Description

– Clozapine N-oxide is the major metabolite of Clozapine and is blood-brain barrier permeable. Clozapine N-oxide is an agonist of DREADDs and activates the DREADD receptors hM3Dq and hM4Di. Clozapine N-oxide is also a dopamine antagonist and selective muscarinic M4 receptor agonist.

Web ID

– T4494

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C18H19ClN4O

Citations

– 1. Ma X, Li L, Li Z, et al. eEF2 in the prefrontal cortex promotes excitatory synaptic transmission and social novelty behavior. EMBO reports. 2022: e54543. 2. Wang Y, Liu N, Ma L, et al.Ventral Hippocampal CA1 Pyramidal Neurons Encode Nociceptive Information.Neuroscience Bulletin.2023: 1-17.

References

– Jendryka M, et al. Pharmacokinetic and pharmacodynamic actions of clozapine-N-oxide, clozapine, and compound 21 in DREADD-based chemogenetics in mice. Sci Rep. 2019 Mar 14;9(1):4522.

CAS Number

– 34233-69-7

Molecular Weight

– C18H19ClN4O

Compound Purity

– 0.9865

SMILES

– CN1(=O)CCN(C=2C=3C(NC=4C(N2)=CC(Cl)=CC4)=CC=CC3)CC1

Pathway

– GPCR/G Protein|||Metabolism|||Neuroscience

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

Clozapine N-Oxide

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