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Products Details
Product Description
– Clemizole is an H1 histamine receptor antagonist, is found to substantially inhibit HCV replication. Clemizole is an inhibitor of TRPC5 channel. The IC50 of Clemizole for RNA binding by NS4B is 24±1 nM, whereas its EC50 for viral replication is 8 µM.
Web ID
– HY-30234
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C19H20ClN3
References
– [1]Nishimura T, et al. Using chimeric mice with humanized livers to predict human drug metabolism and a drug-drug interaction. J Pharmacol Exp Ther. 2013 Feb;344(2):388-96.|[2]Einav S, et al. Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis. Nat Biotechnol. 2008 Sep;26(9):1019-27|[3]Richter JM, et al. Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5. Mol Pharmacol. 2014 Nov;86(5):514-21
CAS Number
– 442-52-4
Molecular Weight
– 325.84
SMILES
– ClC1=CC=C(C=C1)CN2C(CN3CCCC3)=NC4=CC=CC=C24
Clinical Information
– Launched
Research Area
– Cancer; Endocrinology; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– HCV;HCV Protease;Histamine Receptor;TRP Channel
Isoform
– H1 Receptor
Pathway
– Anti-infection;GPCR/G Protein;Immunology/Inflammation;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling
Product type
– Reference compound
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