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Cediranib
Price range: 56 CAD through 1,251 CAD
Products Details
Product Description
– Cediranib (AZD2171) (AZD2171) is a highly potent (IC50 < 1 nmol/L) ATP-competitive inhibitor of recombinant KDR tyrosine kinase in vitro, also inhibits Flt1/4 (IC50: 5 nM/≤3 nM), similar activity against PDGFRβ and c-Kit, selective more for VEGFR than PDGFR-α (36-fold), CSF-1R (110-fold), and Flt3 (1000-fold) in HUVEC cells.
Web ID
– T2500
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C25H27FN4O3
Citations
– 1. Zhang J, Guo H, Wang L, et al.Cediranib enhances the transcription of MHC-I by upregulating IRF-1.Biochemical Pharmacology.2024: 116036.
References
– Wedge SR, et al. Cancer Res, 2005, 65(10), 4389-4400.
CAS Number
– 288383-20-0
Molecular Weight
– C25H27FN4O3
Compound Purity
– 0.9978
SMILES
– O(C=1C2=C(C=C(OCCCN3CCCC3)C(OC)=C2)N=CN1)C=4C(F)=C5C(=CC4)NC(C)=C5
Pathway
– Angiogenesis|||Tyrosine Kinase/Adaptors|||Autophagy
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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