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Products Details
Product Description
– CCR1 antagonist 11 hydrochloride (A1B1) is an orally active CCR1 antagonist with the IC50 values of 0.03 μM, 0.58 μM and 0.32 μM for hCCR1, mCCR1 and rCCR1, respectively. CCR1 antagonist 11 hydrochloride can be used in the study of rheumatoid arthritis and other related inflammatory diseases[1].
Web ID
– HY-114097A
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C23H26Cl2FN3O2
References
– [1]Laszlo Revesz, et al. Novel CCR1 antagonists with oral activity in the mouse collagen induced arthritis. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5160-4.
Molecular Weight
– 466.38
SMILES
– C[C@@H]1CN(CCN1C(/C=C/C2=C(NC(C)=O)C=C(Cl)C=C2)=O)CC3=CC=C(F)C=C3.Cl
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– CCR
Isoform
– CCR1
Pathway
– GPCR/G Protein;Immunology/Inflammation
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
