CC-90005

$1,280$10,800

Products Details

Product Description

– CC-90005 is a potent, selective and orally active inhibitor of protein kinase C-θ (PKC-θ), with an IC50 of 8 nM. CC-90005 shows selectivity for PKC-θ over PKC-δ (IC50=4440 nM). CC-90005 can inhibit T cell activation by inhibiting IL-2 expression[1].

Web ID

– HY-132304

Storage Temperature

– -20°C, 3 years; 4°C, 2 years (Powder)

Shipping

– Room Temperature

Applications

– COVID-19-immunoregulation

Molecular Formula

– C21H27F2N7O2

References

– [1]Papa P, et, al. Discovery of the Selective Protein Kinase C-θ Kinase Inhibitor, CC-90005. J Med Chem. 2021 Aug 26;64(16):11886-11903.

CAS Number

– 1799574-70-1

Molecular Weight

– 447.48

Compound Purity

– 99.98

SMILES

– N#CC1=CN=C(NCC2=CN=CN=C2OCC(F)(F)C)N=C1N[C@H]3CC(C)(C)[C@@H](O)CC3

Clinical Information

– Phase 1

Research Area

– Inflammation/Immunology

Solubility

– DMSO : 62.5 mg/mL (ultrasonic)

Target

– PKC

Isoform

– PKCθ

Pathway

– Epigenetics;TGF-beta/Smad

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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