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Products Details
Product Description
– Cathepsin C-IN-4 (compound SF27) is a potent Cathepsin C (Cat C) inhibitor, with an IC50 of 65.6 nM. Cathepsin C-IN-4 also inhibits THP-1 and U937 cell, with IC50 values of 203.4 and 177.6 nM, respectively[1].
Web ID
– HY-146581
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C21H14ClF3N4S
References
– [1]Chen X, et al. Non-peptidyl non-covalent cathepsin C inhibitoEEr bearing a unique thiophene-substituted pyridine: Design, structure-activity relationship and anti-inflammatory activity in vivo. Eur J Med Chem. 2022 Jun 5;236:114368.
CAS Number
– 2825567-86-8
Molecular Weight
– 446.88
SMILES
– FC(F)(C1=CC=CC(NC2=C(C=NC(NC3=CC=CC(C4=CSC=C4)=C3)=N2)Cl)=C1)F
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Cathepsin
Isoform
– Cathepsin C
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
