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Capivasertib
Price range: 54 CAD through 1,029 CAD
Products Details
Product Description
– Capivasertib (AZD5363) is a broad-spectrum AKT inhibitor with inhibitory activity against Akt1, Akt2, and Akt3 (IC50=3/7/7 nM) with oral activity. Capivasertib has antitumor activity for the treatment of breast cancer.
Web ID
– T1920
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C21H25ClN6O2
Citations
– 1. Weng Q, Zhao M, Zheng J, et al. STAT3 dictates β-cell apoptosis by modulating PTEN in streptozocin-induced hyperglycemia. Cell Death & Differentiation. 2020, 27(1): 130-145
2. Liu Q, Miao Y, Wang X, et al. Structure-based virtual screening and biological evaluation of novel non-bisphosphonate farnesyl pyrophosphate synthase inhibitors. European Journal of Medicinal Chemistry. 2019: 111905
3. Wang J, Xu X, Wang T, et al. Ceritinib increases sensitivity of AKT inhibitors to gastric cancer. European Journal of Pharmacology. 2021: 173879.
4. Wang J, Xu X, Wang T, et al. Ceritinib increases sensitivity of AKT inhibitors to gastric cancer. European Journal of Pharmacology. 2021: 173879.
5. Bing S, Xiang S, Xia Z, et al.AKT inhibitor Hu7691 induces differentiation of neuroblastoma cells.Acta Pharmaceutica Sinica B.2023
6. Zhang W, Li X, Jiang M, et al.SOCS3 deficiency-dependent autophagy repression promote the survival of early-stage myeloid-derived suppressor cells in breast cancer by activating the Wnt/mTOR pathway.Journal of Leukocyte Biology.2023: qiad020.
7. Zhang K M, Zhao D C, Li Z Y, et al.Inactivated cGAS‐STING Signaling Facilitates Endocrine Resistance by Forming a Positive Feedback Loop with AKT Kinase in ER+ HER2–Breast Cancer.Advanced Science.2024: 2403592.
References
– Wang J, et al. Ceritinib increases sensitivity of AKT inhibitors to gastric cancer. Eur J Pharmacol. 2021 Apr 5;896:173879.
CAS Number
– 1143532-39-1
Molecular Weight
– C21H25ClN6O2
Compound Purity
– 0.9913
SMILES
– NC1(CCN(CC1)c1ncnc2[nH]ccc12)C(=O)N[C@@H](CCO)c1ccc(Cl)cc1
Target
– Antibacterial
Pathway
– Tyrosine Kinase/Adaptors|||Cytoskeletal Signaling|||Autophagy|||PI3K/Akt/mTOR signaling
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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