C188-9
C188-9
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C188-9

SKU T4650-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 61 CAD through 2,128 CAD

Products Details

Product Description

– C188-9 (TTI-101) is a Stat3 inhibitor with an IC50 of 4-7 μM.

Web ID

– T4650

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C27H21NO5S

Citations

– 1. Gu H, Chen C, Hao X, et al. MDH1-mediated malate-aspartate NADH shuttle maintains the activity levels of fetal liver hematopoietic stem cells. Blood. 2020, 136(5): 553-571. 2. He, Qiu‐Rui, et al. The natural product trienomycin A is a STAT3 pathway inhibitor that exhibits potent in vitro and in vivo efficacy against pancreatic cancer. British Journal of Pharmacology.  178.12 (2021): 2496-2515. 3. Guan X, Yang J, Wang W, et al.Dual inhibition of MYC and SLC39A10 by a novel natural product STAT3 inhibitor derived from Chaetomium globosum suppresses tumor growth and metastasis in gastric cancer.Pharmacological Research.2023: 106703.

References

– edell MS, et al. Stat3 signaling in acute myeloid leukemia: ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitor. Blood. 2011 May 26;117(21):5701-9.

CAS Number

– 432001-19-9

Molecular Weight

– C27H21NO5S

Compound Purity

– 0.9919

SMILES

– COc1ccc(cc1)S(=O)(=O)Nc1cc(c(O)c2ccccc12)-c1c(O)ccc2ccccc12

Pathway

– JAK/STAT signaling|||Apoptosis|||Stem Cells

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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