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Butylhydroxyanisole
$50 – $60
Products Details
Product Description
– Butylhydroxyanisole (Butylated hydroxyanisole) is an antioxidant used as a food additive preservative. Butylhydroxyanisole mediates liver toxicity, retardation in reproductive organ development and learning, and sleep deficit. Butylhydroxyanisole exerts neurotoxic effects and leads to disruption of the brain and nerve development[1][2][3]. Butylhydroxyanisole is a ferroptosis inducer[4].
Web ID
– HY-B1066
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Molecular Formula
– C11H16O2
References
– [1]Sunwoo Park, et al. Butylated Hydroxyanisole Exerts Neurotoxic Effects by Promoting Cytosolic Calcium Accumulation and Endoplasmic Reticulum Stress in Astrocytes. J Agric Food Chem. 2019 Aug 28;67(34):9618-9629.|[2]Jiyeon Ham, et al. Butylated Hydroxyanisole Exerts Neurotoxic Effects by Promoting Cytosolic Calcium Accumulation and Endoplasmic Reticulum Stress in Astrocytes. Sci Total Environ. 2020 Feb 1;702:134775.|[3]Lin Luo, et al. Butylated hydroxyanisole induces distinct expression patterns of Nrf2 and detoxification enzymes in the liver and small intestine of C57BL/6 mice. Toxicol Appl Pharmacol. 2015 Nov 1;288(3):339-48.|[4]Jennifer Yinuo Cao, et al. Mechanisms of ferroptosis. Cell Mol Life Sci. 2016 Jun;73(11-12):2195-209.
CAS Number
– 25013-16-5
Molecular Weight
– 180.24
Compound Purity
– 99.78
SMILES
– OC1=CC=C(OC)C=C1C(C)(C)C.OC2=CC=C(OC)C(C(C)(C)C)=C2
Clinical Information
– Phase 3
Research Area
– Inflammation/Immunology; Neurological Disease
Solubility
– DMSO : ≥ 100 mg/mL|H2O : 1 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– Ferroptosis;Reactive Oxygen Species
Pathway
– Apoptosis;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
Product type
– Reference compound
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