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Bucladesine (sodium)
$50 – $96
Products Details
Product Description
– Bucladesine sodium salt (Dibutyryl-cAMP sodium salt) is a stabilized cyclic AMP (cAMP) analog and a selective PKA activator. Bucladesine sodium salt raises the intracellular levels of cAMP. Bucladesine sodium salt is also a phosphodiesterase (PDE) inhibitor. Bucladesine sodium salt has anti-inflammatory activity and can be used for impaired wound healing[1][2][3][4].
Web ID
– HY-B0764
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Molecular Formula
– C18H23N5NaO8P
Citations
– Adv Sci (Weinh). 2021 Oct 31;e2100808.|Cell Commun Signal. 2022 Apr 12;20(1):52.|Cell Stem Cell. 2021 Aug 5;28(8):1362-1379.e7.|Cell Tissue Res. 2022 Feb 11.|Ecotoxicol Environ Saf. 2022 Aug 17;243:113982.|Eur J Pharmacol. 2022 Aug 28;932:175231.|FASEB J. 2020 Oct;34(10):13376-13395.|FEBS Lett. 2021 Oct 23.|Front Microbiol. 2021 Aug 17;12:692693.|Int J Mol Sci. 2022, 23(20), 12595.|Int J Mol Sci. 2023 Feb 8;24(4):3398.|Int J Mol Sci. 2023 Mar 7.|J Bone Miner Metab. 2021 Apr 8.|J Endocrinol. 2019 Sep 1;JOE-19-0284.R2.|J Steroid Biochem Mol Biol. 24 September 2022, 106192.|Pigment Cell Melanoma Res. 2023 Aug 9.|Plants. 2023 Oct 24, 12(21), 3666.|Proteome Sci. 2023 Oct 11;21(1):16.|Reproduction. 2021 May 27;162(1):33-45.|Toxins. 2021 Aug 22;13(8):585.|Exp Ther Med. January 31, 2022.
References
– [1]Salehi F, et al. Effect of bucladesine, pentoxifylline, and H-89 as cyclic adenosine monophosphate analog, phosphodiesterase, and protein kinase A inhibitor on acute pain. Fundam Clin Pharmacol. 2017 Aug;31(4):411-419.|[2]Shimojo M, et al. The cholinergic gene locus is coordinately regulated by protein kinase A II in PC12 cells. J Neurochem. 1998 Sep;71(3):1118-26.|[3]Sharifzadeh, M., et al., Post-training intrahippocampal infusion of nicotine-bucladesine combination causes a synergistic enhancement effect on spatial memory retention in rats. Eur J Pharmacol, 2007. 562(3): p. 212-20.|[4]Mafune, E., M. Takahashi, and N. Takasugi, Effect of vehicles on percutaneous absorption of bucladesine (dibutyryl cyclic AMP) in normal and damaged rat skin. Biol Pharm Bull, 1995. 18(11): p. 1539-43.|[5]Rundfeldt, C., et al., The stable cyclic adenosine monophosphate analogue, dibutyryl cyclo-adenosine monophosphate (bucladesine), is active in a model of acute skin inflammation. Arch Dermatol Res, 2012.
CAS Number
– 16980-89-5
Molecular Weight
– 491.37
Compound Purity
– 99.48
SMILES
– O=C(CCC)O[C@H]1[C@H](N2C(N=CN=C3NC(CCC)=O)=C3N=C2)O[C@@](CO4)([H])[C@@]1([H])OP4(O[Na])=O
Clinical Information
– Launched
Research Area
– Inflammation/Immunology
Solubility
– DMSO : 100 mg/mL (ultrasonic)|H2O : ≥ 50 mg/mL
Target
– Phosphodiesterase (PDE);PKA
Isoform
– PKA
Pathway
– Metabolic Enzyme/Protease;Stem Cell/Wnt
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
