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Products Details
Product Description
– BTK-IN-7 is a potent and selective inhibitor of BTK (IC50=4.0 nM). BTK-IN-7 has high selectivity in both enzymatic (ITK >250-fold, EGFR >2500-fold) and cellular levels (ITK >227-fold, EGFR 27-fold). BTK-IN-7 also has potent antitumor activity[1].
Web ID
– HY-143900
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C30H32N6O4
References
– [1]Dou D, et al. Discovery of Pteridine-7(8H)-one Derivatives as Potent and Selective Inhibitors of Bruton’s Tyrosine Kinase (BTK). J Med Chem. 2022;65(3):2694-2709.
Molecular Weight
– 540.61
SMILES
– O=C1N(C2=NC(NC3=CC(OCCOC)=CC=C3)=NC=C2N=C1C4CCCCC4)C5=CC=CC(NC(C=C)=O)=C5
Clinical Information
– No Development Reported
Research Area
– Cancer; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Btk
Pathway
– Apoptosis;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
