Birinapant
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Birinapant

SKU T6007-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 66 CAD through 795 CAD

Products Details

Product Description

– Birinapant (TL32711) is a synthetic small molecule that is both a peptidomimetic of second mitochondrial-derived activator of caspases (SMAC) and inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins, with potential antineoplastic activity.

Web ID

– T6007

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C42H56F2N8O6

Citations

– 1. Bhatt S, Pioso M S, Olesinski E A, et al. Reduced Mitochondrial Apoptotic Priming Drives Resistance to BH3 Mimetics in Acute Myeloid Leukemia. Cancer Cell. 2020, 38(6): 872-890. e6. 2. Olesinski E A, Bhatia K S, Wang C, et al.Acquired Multidrug Resistance in AML Is Caused by Low Apoptotic Priming in Relapsed Myeloblasts.Blood Cancer Discovery.2024: OF1-OF22.

References

– Allensworth JL, et al. Breast Cancer Res Treat, 2013, 137(2), 359-371.

CAS Number

– 1260251-31-7

Molecular Weight

– C42H56F2N8O6

Compound Purity

– 0.9978

SMILES

– CC[C@H](NC(=O)[C@H](C)NC)C(=O)N1C[C@@H](O)C[C@H]1Cc1c([nH]c2cc(F)ccc12)-c1[nH]c2cc(F)ccc2c1C[C@@H]1C[C@H](O)CN1C(=O)[C@H](CC)NC(=O)[C@H](C)NC

Pathway

– Apoptosis|||Microbiology/Virology|||Proteases/Proteasome

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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