Download Files:
Becatecarin
$502
Only 1000 item(s) left in stock.
Products Details
Product Description
– Becatecarin is a rebeccamycin analog with antitumor effects. Becatecarin intercalates into DNA and inhibites the catalytic activity of topoisomerases I/II.
Web ID
– HY-13565
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C33H34Cl2N4O7
References
– [1]Long BH, Rose WC, Vyas DM, Matson JA, Forenza S. Discovery of antitumor indolocarbazoles: rebeccamycin, NSC 655649, and fluoroindolocarbazoles. Curr Med Chem Anticancer Agents. 2002;2(2):255-266. |[2]Robey RW, Obrzut T, Shukla S, et al. Becatecarin (rebeccamycin analog, NSC 655649) is a transport substrate and induces expression of the ATP-binding cassette transporter, ABCG2, in lung carcinoma cells. Cancer Chemother Pharmacol. 2009;64(3):575-583.
CAS Number
– 119673-08-4
Molecular Weight
– 669.55
SMILES
– ClC1=CC=CC2=C1NC3=C2C4=C(C(N(CCN(CC)CC)C4=O)=O)C5=C3N([C@@H]6O[C@H](CO)[C@@H](OC)[C@H](O)[C@H]6O)C7=C(Cl)C=CC=C75
Clinical Information
– Phase 3
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Topoisomerase
Pathway
– Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
