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B2M/beta 2-Microglobulin Protein, Mouse, Recombinant (hFc)
Price range: 518 CAD through 2,080 CAD
Products Details
Product Description
– The genetic and functional analysis of β2-microglobulin (B2M), a component of the HLA class-I complex.Acquired homozygous loss of B2M that caused lack of cell-surface HLA Class I expression in the tumor and a matched patient-derived xenograft (PDX). Downregulation of B2M was also found in two additional PDXs established from ICI-resistant tumors.
Web ID
– TMPK-00761
Storage Temperature
– -20℃
Shipping
– Blue Ice
References
– Gettinger S, et al. Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer. Cancer Discov. 2017 Dec;7(12):1420-1435. doi: 10.1158/2159-8290.CD-17-0593. Epub 2017 Oct 12. PMID: 29025772; PMCID: PMC5718941.
Molecular Weight
Product type
– Recombinant-Protein
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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