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AZD3759 hydrochloride
Price range: 48 CAD through 685 CAD
Products Details
Product Description
– AZD3759 (hydrochloride) is an effective, orally active and central nervous system-penetrant EGFR inhibitor. At Km ATP concentrations, the IC50s are 0.2/0.3/0.2 nM for EGFR (L858R)/EGFR (wt)/EGFR (exon 19Del).
Web ID
– T4249
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C22H24Cl2FN5O3
References
– Zeng Q, et al. Discovery and Evaluation of Clinicalal Candidate AZD3759, a Potent, Oral Active, Central Nervous System-Penetrant, Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor. J Med Chem. 2015 Oct 22;58(20):8200-15.
CAS Number
– 1626387-81-2
Molecular Weight
– C22H24Cl2FN5O3
Compound Purity
– 0.9941
SMILES
– C[C@@H]1CN(CCN1C(=O)OC2=C(C=C3C(=C2)C(=NC=N3)NC4=C(C(=CC=C4)Cl)F)OC)C.Cl
Pathway
– JAK/STAT signaling|||Angiogenesis|||Tyrosine Kinase/Adaptors
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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