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Products Details
Product Description
– AZ-3 is a potent and selective JAK1 inhibitor with an IC50 of 34 nM.
Web ID
– HY-112442
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C20H28FN7
References
– [1]Grimster NP, et al. Discovery and Optimization of a Novel Series of Highly Selective JAK1 Kinase Inhibitors. J Med Chem. 2018 Jun 28;61(12):5235-5244.
CAS Number
– 2228908-91-4
Molecular Weight
– 385.48
SMILES
– FC1=NC=C(N2C[C@H]3N(C)C[C@@H]2C3)C=C1NC4=NC(N[C@@H](CC)C)=C(C)C=N4
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– JAK
Pathway
– Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
