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Axitinib
Price range: 53 CAD through 349 CAD
For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.
Products Details
Product Description
– Axitinib (AG-013736) is a multi-targeted tyrosine kinase inhibitor that inhibits VEGFR1, VEGFR2, VEGFR3, and PDGFRβ (IC50=4/20/0.4/2 nM). Axitinib has antitumor activity and is used in the treatment of renal cell carcinoma.
For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.
Web ID
– T1452
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C22H18N4OS
Citations
– 1. Huang M, Chen M, Qi M, et al. Perivascular cell‐derived extracellular vesicles stimulate colorectal cancer revascularization after withdrawal of antiangiogenic drugs. Journal of Extracellular Vesicles. 2021, 10(7): e12096.
2. Wei R, Ma Q, Li T, et al. Carbazole alkaloids with antiangiogenic activities from Clausena sanki. Bioorganic Chemistry. 2018 Apr;77:387-392
3. Wei N, Liang J, Peng S, et al. Design, synthesis, and biological evaluation of axitinib derivatives. Molecules. 2018 Mar 23;23(4)
4. Li H, Zhang R, Hu Y, et al.Axitinib attenuates the progression of liver fibrosis by restoring mitochondrial function.International Immunopharmacology.2023, 122: 110555.
References
– Hu-Lowe DD, et al. Nonclinical antiangiogenesis and antitumor activities of axitinib (AG-013736), an oral, potent, and selective inhibitor of vascular endothelial growth factor receptor tyrosine kinases 1, 2, 3. Clin Cancer Res. 2008 Nov 15;14(22):7272-83.
CAS Number
– 319460-85-0
Molecular Weight
– C22H18N4OS
Compound Purity
– 0.9974
SMILES
– C(=C/C1=CC=CC=N1)C=2C=3C(=CC(SC4=C(C(NC)=O)C=CC=C4)=CC3)NN2
Target
– Others
Pathway
– Tyrosine Kinase/Adaptors|||Angiogenesis
Product type
– Small Compound
New Class
– Top-SmallMol
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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