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AVE 0991
$180 – $1,390
Products Details
Product Description
– AVE 0991 is a nonpeptide and orally active angiotensin-(1-7) receptor agonist with an IC50 of 21 nM[1].
Web ID
– HY-15778
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C29H32N4O5S2
Citations
– Aging (Albany NY). 2018 Apr 17;10(4):645-657. |Diabetes. 2017 Aug;66(8):2201-2212. |Exp Anim. 2022 Aug 8.|Front Aging Neurosci. 2021 Feb 15.|J Hepatol. 2022 Nov 9;S0168-8278(22)03285-8.|J Inflamm Res. 2021 Dec 18;14:7007-7019.|PLoS One. 2015 Nov 5;10(11):e0142087.|Redox Biol. 2019 Jan;20:75-86.|Research Square Preprint. 2021 Nov.|Blood. 2015 Jan 22;125(4):710-9.
References
– [1]Ferreira AJ, et al. The nonpeptide angiotensin-(1-7) receptor Mas agonist AVE-0991 attenuates heart failure induced by myocardial infarction. Am J Physiol Heart Circ Physiol. 2007 Feb;292(2):H1113-9.|[2]Pinheiro SV, et al. Nonpeptide AVE 0991 is an angiotensin-(1-7) receptor Mas agonist in the mouse kidney. Hypertension. 2004 Oct;44(4):490-6.|[3]Wiemer G, et al. AVE 0991, a nonpeptide mimic of the effects of angiotensin-(1-7) on the endothelium. Hypertension. 2002 Dec;40(6):847-52.|[4]Mo J, et al. AVE 0991 attenuates oxidative stress and neuronal apoptosis via Mas/PKA/CREB/UCP-2 pathway after subarachnoid hemorrhage in rats. Redox Biol. 2018 Sep 28;20:75-86.
CAS Number
– 304462-19-9
Molecular Weight
– 580.72
Compound Purity
– 99.92
SMILES
– O=S(C1=C(C2=CC=C(CN3C(C=O)=C(OC)N=C3C4=CC=CC=C4)C=C2)C=C(CC(C)C)S1)(NC(NCC)=O)=O
Clinical Information
– No Development Reported
Research Area
– Cardiovascular Disease; Endocrinology
Solubility
– DMSO : 41.67 mg/mL (ultrasonic)
Target
– Angiotensin Receptor
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
