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Products Details
Product Description
– AV123 (compound 12) is a non-cytotoxic RIPK1 inhibitor (IC50=12.12 µM). AV123 blocks the TNF-α-induced necroptotic (EC50=1.7 μM) but not the apoptotic cell death. AV123 can be used in the study of necrotic chronic conditions such as ischemia-reperfusion injury of the brain, heart and kidney, inflammatory diseases, neurodegenerative diseases and infectious diseases[1].
Web ID
– HY-151369
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C11H14N4O2
References
– [1]Benchekroun M, et al. Discovery of simplified benzazole fragments derived from the marine benzosceptrin B as necroptosis inhibitors involving the receptor interacting protein Kinase-1. Eur J Med Chem. 2020 Sep 1;201:112337.
CAS Number
– 233605-81-7
Molecular Weight
– 234.25
SMILES
– O=[N+](C1=CC=C2C(NC(NCCCC)=N2)=C1)[O-]
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– RIP kinase
Pathway
– Apoptosis
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
