Products Details

Product Description

– AV123 (compound 12) is a non-cytotoxic RIPK1 inhibitor (IC50=12.12 µM). AV123 blocks the TNF-α-induced necroptotic (EC50=1.7 μM) but not the apoptotic cell death. AV123 can be used in the study of necrotic chronic conditions such as ischemia-reperfusion injury of the brain, heart and kidney, inflammatory diseases, neurodegenerative diseases and infectious diseases[1].

Web ID

– HY-151369

Shipping

– Room temperature

Applications

– Metabolism-protein/nucleotide metabolism

Molecular Formula

– C11H14N4O2

References

– [1]Benchekroun M, et al. Discovery of simplified benzazole fragments derived from the marine benzosceptrin B as necroptosis inhibitors involving the receptor interacting protein Kinase-1. Eur J Med Chem. 2020 Sep 1;201:112337.

CAS Number

– 233605-81-7

Molecular Weight

– 234.25

SMILES

– O=[N+](C1=CC=C2C(NC(NCCCC)=N2)=C1)[O-]

Clinical Information

– No Development Reported

Research Area

– Metabolic Disease; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Solubility

– 10 mM in DMSO

Target

– RIP kinase

Pathway

– Apoptosis

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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