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Products Details
Product Description
– Aurora/LIM kinase-IN-1 (Compound F114) is a potent and dual inhibitor of aurora and lim kinase. Aurora kinases and lim kinases are involved in neoplastic cell division and cell motility, respectively. Aurora/LIM kinase-IN-1 inhibits GBM proliferation and invasion. Aurora/LIM kinase-IN-1 is a promising new scaffold for dual aurora/lim kinase inhibitors that may be used in future agent development efforts for GBM, and potentially other cancers[1].
Web ID
– HY-144438
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C16H20N6O
References
– [1]Rybin MJ, et al. A dual aurora and lim kinase inhibitor reduces glioblastoma proliferation and invasion. Bioorg Med Chem Lett. 2022;61:128614.
Molecular Weight
– 312.37
SMILES
– CC(N1C=C(C=N1)NC2=NC=C3C=CC(N(C3=N2)C(C)C)=O)C
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Aurora Kinase;LIM Kinase (LIMK)
Pathway
– Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
