Download Files:
Products Details
Product Description
– Aurora A inhibitor 2 (Compound 16h) is a potent Aurora A kinase inhibitor with an IC50 of 21.94 nM. Aurora A inhibitor 2 induces caspase-dependent apoptosis in MDA-MB-231 cells[1].
Web ID
– HY-146037
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C24H26N6O3
References
– [1]Chengcheng Fan, et al. Design, synthesis, biological evaluation of 6-(2-amino-1H-benzo[d]imidazole-6-yl)quinazolin-4(3H)-one derivatives as novel anticancer agents with Aurora kinase inhibition. Eur J Med Chem. 2020 Mar 15;190:112108.
CAS Number
– 2412144-74-0
Molecular Weight
– 446.50
SMILES
– CCC(NC1=NC2=CC=C(C3=CC4=C(N=CN(CCN5CCOCC5)C4=O)C=C3)C=C2N1)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Aurora Kinase
Isoform
– Aurora A;Aurora B
Pathway
– Apoptosis;Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
