Download Files:
AT7519 (Hydrochloride)
$66 – $275
Products Details
Product Description
– AT7519 Hydrochloride is a potent inhibitor of CDKs, with IC50s of 210, 47, 100, 13, 170, and <10 nM for CDK1, CDK2, CDK4 to CDK6, and CDK9, respectively.
Web ID
– HY-50943
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C16H18Cl3N5O2
Citations
– Cell Chem Biol. 2018 Feb 15;25(2):135-142.e5.|Harvard Medical School LINCS LIBRARY|Exp Eye Res. 2023 Jan 22;227:109391.|Glycobiology. 2022 Jun 16;cwac038.|Harvard Medical School LINCS LIBRARY|Oncogene. 2023 Oct 16.|RNA Biol. 2021 Sep 30;1-8.|Sci Rep. 2021 Mar 8;11(1):5374.|Sci Transl Med. 2018 Jul 18;10(450):eaaq1093.
References
– [1]Santo L, et al. AT7519, A novel small molecule multi-cyclin-dependent kinase inhibitor, induces apoptosis in multiple myeloma via GSK-3beta activation and RNA polymerase II inhibition. Oncogene. 2010 Apr 22;29(16):2325-36.|[2]Squires MS, et al. Biological characterization of AT7519, a small-molecule inhibitor of cyclin-dependent kinases, in human tumor cell lines. Biological characterization of AT7519, a small-molecule inhibitor of cyclin-dependent kinases, in human tumor cell lines.|[3]Squires MS, et al. AT7519, a cyclin-dependent kinase inhibitor, exerts its effects by transcriptional inhibition in leukemia cell lines and patient samples. Mol Cancer Ther. 2010 Apr;9(4):920-8.
CAS Number
– 902135-91-5
Molecular Weight
– 418.71
Compound Purity
– 99.42
SMILES
– O=C(C(C(Cl)=CC=C1)=C1Cl)NC2=CNN=C2C(NC3CCNCC3)=O.[H]Cl
Clinical Information
– Phase 2
Research Area
– Cancer
Solubility
– DMSO : ≥ 300 mg/mL|H2O : 8.33 mg/mL (ultrasonic)
Target
– Apoptosis;CDK
Isoform
– CDK1;CDK2;CDK4;CDK5;CDK6;CDK7;CDK9
Pathway
– Apoptosis;Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
