AS1517499
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AS1517499

SKU T4476-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 54 CAD through 1,792 CAD

Products Details

Product Description

– AS1517499 is a potent STAT6 inhibitor with IC50 of 21 nM

Web ID

– T4476

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C20H20ClN5O2

Citations

– 1. Qin R, Wang T, He W, et al.Jak2/STAT6/c-Myc pathway is vital to the pathogenicity of Philadelphia-positive acute lymphoblastic leukemia caused by P190BCR-ABL.Cell Communication and Signaling.2023, 21(1): 27. 2. Tao Y, Xu L, Liu X, et al.Chitosan-coated artesunate protects against ulcerative colitis via STAT6-mediated macrophage M2 polarization and intestinal barrier protection.International Journal of Biological Macromolecules.2023: 127680.

References

– Nagashima S, et al. Synthesis and evaluation of 2-{[2-(4-hydroxyphenyl)-ethyl]amino}pyrimidine-5-carboxamide derivatives as novel STAT6 inhibitors. Bioorg Med Chem. 2007 Jan 15;15(2):1044-55.

CAS Number

– 919486-40-1

Molecular Weight

– C20H20ClN5O2

Compound Purity

– 0.987

SMILES

– NC(=O)c1cnc(NCCc2ccc(O)c(Cl)c2)nc1NCc1ccccc1

Pathway

– JAK/STAT signaling|||Stem Cells

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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