ARN-3236
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ARN-3236

SKU T5993-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 88 CAD through 2,336 CAD

Products Details

Product Description

– ARN-3236 is an orally active and selective inhibitor of salt-inducible kinase 2 (SIK2), with IC50 values of <1 nM for SIK2, 21.63 nM for SIK1, and 6.63 nM for SIK3. ARN-3236 exhibits anti-cancer activity.

Web ID

– T5993

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C19H16N2O2S

Citations

– 1. Liu Y, Tang W, Ji C, et al. The selective SIK2 inhibitor ARN-3236 produces strong antidepressant-like efficacy in mice via the hippocampal CRTC1-CREB-BDNF pathway. Frontiers in pharmacology. 2020, 11. 2. Zou L, Hong D, Li K, et al. Salt-inducible kinase 2 (SIK2) inhibitor ARN-3236 attenuates bleomycin-induced pulmonary fibrosis in mice. BMC Pulmonary Medicine. 2022, 22(1): 1-11

References

– Zhou J , Alfraidi A , Zhang S , et al. A novel compound ARN-3236 inhibits Salt Inducible Kinase 2 and sensitizes ovarian cancer cell lines and xenografts to paclitaxel[J]. Clinical Cancer Research, 2016:1078-0432.CCR-16-1562.

CAS Number

– 1613710-01-2

Molecular Weight

– C19H16N2O2S

Compound Purity

– 0.9957

SMILES

– COc1ccc(-c2c[nH]c3nccc(-c4ccsc4)c23)c(OC)c1

Pathway

– PI3K/Akt/mTOR signaling|||Chromatin/Epigenetic

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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