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APX-115 (free base)
$120 – $1,100
Products Details
Product Description
– APX-115 free base (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 free base effectively prevents kidney injury[1].
Web ID
– HY-120801A
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C17H17N3O
References
– [1]Cha JJ, et al. APX-115, a first-in-class pan-NADPH oxidase (Nox) inhibitor, protects db/db mice from renal injury. Lab Invest. 2017 Apr;97(4):419-431.|[2]Kwon G, et al. A novel pan-Nox inhibitor, APX-115, protects kidney injury in streptozotocin-induced diabetic mice: possible role of peroxisomal and mitochondrial biogenesis. Oncotarget. 2017 Jun 16;8(43):74217-74232.
CAS Number
– 1270084-92-8
Molecular Weight
– 279.34
Compound Purity
– 98.11
SMILES
– OC1=C(CCC)C(C2=CC=CC=C2)=NN1C3=NC=CC=C3
Clinical Information
– Phase 2
Research Area
– Endocrinology; Inflammation/Immunology
Solubility
– DMSO : 250 mg/mL (ultrasonic)
Target
– NADPH Oxidase
Isoform
– NOX1;NOX2;NOX4
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
