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Products Details
Product Description
– APS-2-79 hydrochloride is a KSR-dependent MEK antagonist. APS-2-79 inhibits ATPbiotin binding to KSR2 within the KSR2-MEK1 complexe with an IC50 of 120 nM. APS-2-79 makes the stabilization of the KSR inactive state antagonizes oncogenic Ras-MAPK signaling[1].
Web ID
– HY-100627A
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C23H22ClN3O3
References
– [1]Dhawan NS, et al. Small molecule stabilization of the KSR inactive state antagonizes oncogenic Ras signalling. Nature. 2016 Sep 1;537(7618):112-116.
CAS Number
– 2002381-31-7
Molecular Weight
– 423.89
SMILES
– CC1=CC(OC2=CC=CC=C2)=CC=C1NC3=C4C=C(OC)C(OC)=CC4=NC=N3.Cl
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– MEK
Isoform
– MEK1
Pathway
– MAPK/ERK Pathway
Product type
– Reference compound
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