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Products Details
Product Description
– APN/AKT-IN-1 is a potent and dual inhibitor of APN and AKT with IC50s of 0.21 and 0.27 μM, respectively. APN/AKT-IN-1 can effectively inhibit the phosphorylation of GSK3β, the intracellular substrate of AKT[1].
Web ID
– HY-145244
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C18H27N7O3
References
– [1]Liu Q, et al. Design, Synthesis, and Biological Evaluation of APN and AKT Dual-Target Inhibitors. ACS Med Chem Lett. 2021;12(12):1932-1941.
CAS Number
– 2854340-31-9
Molecular Weight
– 389.45
SMILES
– NC1(C(N[C@H](CC(C)C)C(NO)=O)=O)CCN(CC1)C2=NC=NC3=C2C=CN3
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Akt
Pathway
– PI3K/Akt/mTOR
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
