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Products Details
Product Description
– APJ receptor agonist 6 (compound 9) is a potent APJ (apelin receptor) agonist, with Ki of 1.3 μM. APJ receptor agonist 6 has EC50 values of 0.070 , 0.097, and 0.063 μM for calcium, cAMP, and β-arrestin, respectively[1].
Web ID
– HY-147751
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C29H34FN3O5
References
– [1]Narayanan S, et al. Identification of potent pyrazole based APELIN receptor (APJ) agonists. Bioorg Med Chem. 2020 Feb 15;28(4):115237.
CAS Number
– 1965244-85-2
Molecular Weight
– 523.60
SMILES
– COC1=CC=CC(OC)=C1C2=CC(C(N[C@H](CC(O)=O)CCC3CCCCC3)=O)=NN2C4=CC=C(C=C4)F
Clinical Information
– No Development Reported
Research Area
– Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– Apelin Receptor (APJ);Arrestin
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
