AP14145 hydrochloride
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AP14145 hydrochloride

SKU T39963-5 mg Category Brand:

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Product Description

– AP14145 hydrochloride is a potent negative allosteric modulator of K Ca 2 (SK) channels, specifically targeting K Ca 2.2 (SK2) and K Ca 2.3 (SK3) channels with an IC 50 of 1.1 μM. Inhibition of AP14145 hydrochloride is highly influenced by S508 and A533 amino acids present in the channel. This compound effectively extends the atrial effective refractory period (AERP) in rats and exhibits antiarrhythmic properties in a Vernakalant-resistant porcine model of atrial fibrillation (AF).

Web ID

– T39963

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C18H18ClF3N4O

References

– Rafel Simó-Vicens, et al. A New Negative Allosteric Modulator, AP14145, for the Study of Small Conductance Calcium-Activated Potassium (K Ca 2) Channels. Br J Pharmacol. 2017 Dec;174(23):4396-4408.

CAS Number

– 2387505-59-9

Molecular Weight

– C18H18ClF3N4O

SMILES

– Cl.C[C@@H](Nc1nc2cccc(NC(C)=O)c2[nH]1)c1cccc(c1)C(F)(F)F

Pathway

– Others

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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