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Products Details
Product Description
– Anti-Aβ agent 1A (compound M15) has potent activity against amyloid-β. Anti-Aβ agent 1A possesses can significantly inhibit LPS-induced levels of IL-1β, IL-6 and TNF-α, and reduces the apoptosis of SH-SY5Y induced by H2O2 through mitochondria pathway. Anti-Aβ agent 1A possesses antioxidant, anti-inflammatory, anti-Aβ toxicity and neuroprotective activities. Anti-Aβ agent 1A can be used for researching Alzheimer’s disease (AD)[1].
Web ID
– HY-146483
Shipping
– Room temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C35H49NO4
References
– [1]Yang GX,et al. Design, synthesis and evaluation of diosgenin carbamate derivatives as multitarget anti-Alzheimer’s disease agents. Eur J Med Chem. 2020 Feb 1;187:111913.
Molecular Weight
– 547.77
SMILES
– C[C@H]1C2C(O[C@@]13OC[C@@H](CC3)C)CC4C5CC=C6C[C@H](CC[C@@]6(C5CC[C@@]42C)C)OC(NCC7=CC=CC=C7)=O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology; Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Amyloid-β
Pathway
– Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
