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Amiodarone (hydrochloride)
$55 – $119
Products Details
Product Description
– Amiodarone hydrochloride, a benzofuran-based Class III antiarrhythmic agent, inhibits WT outwardIhERG tails with an IC50 of ∼45 nM[1]. Amiodarone hydrochloride induces cell proliferation and myofibroblast differentiation via ERK1/2 and p38 MAPK signaling in fibroblasts[2]. Amiodarone hydrochloride can be used in the research of both supraventricular and ventricular arrhythmias[1].
Web ID
– HY-14188
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture and light)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C25H30ClI2NO3
Citations
– Front Bioeng Biotechnol. 2022 Mar 17;10:826093.|Viruses. 2021 Jun 28;13(7):1255.|Biochem Biophys Res Commun. 2020 Feb 19;522(4):862-868.|Biotechnol Bioeng. 2021 Sep 3.|Cell. 2022 Dec 8;185(25):4801-4810.e13.|Cell. 2023 Nov 22;186(24):5363-5374.e16.|Ecotoxicol Environ Saf. 2021 Apr 1;212:111991.|Patent. US20180263995A1.
References
– [1]Jie Weng, et al. Amiodarone induces cell proliferation and myofibroblast differentiation via ERK1/2 and p38 MAPK signaling in fibroblasts. Biomed Pharmacother. 2019 Jul;115:108889.|[2]Yihong Zhang,et al. Interactions between amiodarone and the hERG potassium channel pore determined with mutagenesis and in silico docking. Biochem Pharmacol. 2016 Aug 1;113:24-35.|[3]Sabrina Le Bouter, et al. Long-term amiodarone administration remodels expression of ion channel transcripts in the mouse heart. Circulation. 2004 Nov 9;110(19):3028-35.
CAS Number
– 19774-82-4
Molecular Weight
– 681.77
Compound Purity
– 99.96
SMILES
– CCCCC1=C(C(C2=CC(I)=C(OCCN(CC)CC)C(I)=C2)=O)C3=C(O1)C=CC=C3.Cl
Clinical Information
– Launched
Research Area
– Cardiovascular Disease; Cancer
Solubility
– DMSO : 24.5 mg/mL (ultrasonic;warming)
Target
– Autophagy;Potassium Channel
Pathway
– Autophagy;Membrane Transporter/Ion Channel
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
