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Amiloride (hydrochloride)
$66 – $119
Products Details
Product Description
– Amiloride hydrochloride (MK-870 hydrochloride) is an inhibitor of both epithelial sodium channel (ENaC[1]) and urokinase-type plasminogen activator receptor (uTPA[2]). Amiloride hydrochloride is a blocker of polycystin-2 (PC2; TRPP2[3]) channel.
Web ID
– HY-B0285A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C6H9Cl2N7O
Citations
– Biomaterials. 2022 May;284:121529.|Br J Pharmacol. 2020 Aug;177(15):3473-3488. |Cell Rep. 2022 May 31;39(9):110880.|Int J Biol Macromol. 14 March 2022.|iScience. 19 October 2022, 105403.|J Ethnopharmacol. 2022 Mar 5;115171.|J Neuroinflammation. 2022 Feb 22;19(1):53.|Sci Total Environ. 2021, 146523.|Theranostics. 2020 May 17;10(15):6581-6598. |ACS Nano. 2023 Apr 14.|Am J Transl Res. 2021 Jul 15;13(7):7538-7555.|Cell Commun Signal. 2023 May 4;21(1):99.|Cell Metab. 2022 Dec 6;34(12):2018-2035.e8.|Cell Physiol Biochem. 2018;51(6):2564-2574. |Commun Biol. 2022 Nov 14;5(1):1248.|Environ Sci Technol. 2021 Feb 11.|J Am Chem Soc. 2018 Dec 12;140(49):17234-17240.|J Nanobiotechnology. 2020 Jan 31;18(1):26.|J Pharmaceut Biomed. 2020, 113870.|Microb Pathog. 2019 Jul 18:103638. |Nanotechnology. 2018 Feb 23;29(8):085101.|Small Methods. 2020 Dec 18.|Theranostics. 2019 May 31;9(13):3732-3753.|Transl Res. 2023 Sep 5;S1931-5244(23)00143-3.
References
– [1]Ji, H.L., et al. delta ENaC: a novel divergent amiloride-inhibitable sodium channel. Am J Physiol Lung Cell Mol Physiol, 2012. 303(12): p. L1013-26.|[2]Teiwes J, et al. Epithelial sodium channel inhibition in cardiovascular disease. A potential role for amiloride. Am J Hypertens. 2007 Jan;20(1):109-17.|[3]Giamarchi A, et al. A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes. EMBO J. 2010 Apr 7;29(7):1176-91.
CAS Number
– 2016-88-8
Molecular Weight
– 266.09
Compound Purity
– 99.81
SMILES
– O=C(C1=NC(Cl)=C(N)N=C1N)NC(N)=N.Cl
Clinical Information
– Launched
Research Area
– Metabolic Disease; Cardiovascular Disease
Solubility
– DMSO : ≥ 100 mg/mL|H2O : 7.14 mg/mL (ultrasonic)
Target
– Apoptosis;Sodium Channel;TRP Channel
Pathway
– Apoptosis;Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
