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Afatinib
Price range: 48 CAD through 506 CAD
Products Details
Product Description
– Afatinib (BIBW 2992) is an irreversible inhibitor of the EGFR family (EGFR-wt, EGFR-L858R, EGFR-L858R/T790M, and HER2) with IC50s of 0.5 nM, 0.4 nM, 10 nM, and 14 nM, respectively.
Web ID
– T21312
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C24H25ClFN5O3
Citations
– 1. Liang J, Bi G, Sui Q, et al.Transcription factor ZNF263 enhances EGFR-targeted therapeutic response and reduces residual disease in lung adenocarcinoma.Cell Reports.2024, 43(2).
2. Wei X, Zhang G, Liu Q, et al.Almonertinib and alflutinib show novel inhibition on rare EGFR S768I mutant cells.Clinical and Translational Oncology.2024: 1-16.
3. Long Y, Jia X, Chu L.Insight into the structure, function and the tumor suppression effect of gasdermin E.Biochemical Pharmacology.2024: 116348.
4. Zhang C, Sun Y X, Yi D C, et al.Neoadjuvant sintilimab plus chemotherapy in EGFR-mutant NSCLC: Phase 2 trial interim results (NEOTIDE/CTONG2104).Cell Reports Medicine.2024
5. Tu R, Ma J, Chen Y, et al.USP7 depletion potentiates HIF2α degradation and inhibits clear cell renal cell carcinoma progression.Cell Death & Disease.2024, 15(10): 749.
References
– Wong CH, et al. Preclinical evaluation of afatinib (BIBW2992) in esophageal squamous cell carcinoma (ESCC). Am J Cancer Res. 2015 Nov 15;5(12):3588-99.
CAS Number
– 850140-72-6
Molecular Weight
– C24H25ClFN5O3
Compound Purity
– 0.9988
SMILES
– N(C=1C2=C(C=C(O[C@H]3CCOC3)C(NC(/C=C/CN(C)C)=O)=C2)N=CN1)C4=CC(Cl)=C(F)C=C4
Pathway
– Autophagy|||Tyrosine Kinase/Adaptors|||Angiogenesis|||JAK/STAT signaling
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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