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A-366
Price range: 48 CAD through 893 CAD
Products Details
Product Description
– A-366 is a highly selective peptide-competitive histone methyltransferase G9a inhibitor with IC50s of 3.3 and 38 nM for G9a and GLP, respectively.It is more than 1,000-fold selective for G9a and GLP over the other 21 methyltransferases. It is an inhibitor of the Spindlin1-H3K4me3 interaction with an IC50 of 182.6 nM.It exhibits high affinity for human H3R with a Ki value of 17 nM, and shows subtype selectivity between subgroups of the histaminergic and dopaminergic receptor families.
Web ID
– T3624
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C19H27N3O2
Citations
– 1. Zhang W, Yang D, Yuan Y, et al. Muscular G9a regulates muscle-liver-fat axis by musclin under overnutrition in female mice. Diabetes. 2020
2. Yang D, Fan Y, Xiong M, et al.Loss of renal tubular G9a benefits acute kidney injury by lowering focal lipid accumulation via CES1.EMBO reports.2023: e56128.
References
– Pappano WN, et al. PLoS One. 2015, 10(7):e0131716.
CAS Number
– 1527503-11-2
Molecular Weight
– C19H27N3O2
Compound Purity
– 0.9853
SMILES
– COc1cc2c(cc1OCCCN1CCCC1)N=C(N)C21CCC1
Target
– Autophagy|||MDM-2/p53
Pathway
– Chromatin/Epigenetic
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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