A-1210477
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A-1210477

SKU T2632-2 mg Category Brand:

Price range: 54 CAD through 1,579 CAD

Products Details

Product Description

– A-1210477 is an effective and specific MCL-1 and Bcl-2 inhibitor (Ki/IC50: 0.454/26.2 nM).

Web ID

– T2632

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C46H55N7O7S

Citations

– 1. Zhu P J, Yu Z Z, Lv Y F, et al. Discovery of 3, 5-Dimethyl-4-Sulfonyl-1 H-Pyrrole-Based Myeloid Cell Leukemia 1 Inhibitors with High Affinity, Selectivity, and Oral Bioavailability. Journal of Medicinal Chemistry. 2021, 64(15): 11330-11353. 2. Gong Q, Li C, Wang H, et al.Discovery of Phenylpyrazole Derivatives as a New Class of Selective Inhibitors of MCL-1 with Antitumor Activity.ACS Omega.2024

References

– Leverson JD, et al. Cell Death Dis. 2015, 6:e1590. doi: 10.1038/cddis.2014.561.

CAS Number

– 1668553-26-1

Molecular Weight

– C46H55N7O7S

Compound Purity

– 0.9917

SMILES

– C(CN1CCOCC1)N2C3=C(C=CC=C3C(CCCOC=4C5=C(C=CC4)C=CC=C5)=C2C(O)=O)C6=C(COC7=CC=C(C=C7)N8CCN(S(N(C)C)(=O)=O)CC8)N(C)N=C6C

Pathway

– Apoptosis

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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