Download Files:
5-HT2B antagonist-1
$80 – $650
Products Details
Product Description
– 5-HT2B antagonist-1 is an orally active 5-HT2B receptor antagonist with an IC50 value of 33.4 nM. 5-HT2B antagonist-1 can be used in studies of diseases characterized by 5-HT2B receptor signaling, such as hepatocellular carcinoma, cardiovascular disease or gastrointestinal disease[1][2].
Web ID
– HY-147203
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C11H14BrN5
References
– [1]Xiang Ma, et al. Synthesis and in vitro evaluation of 2,4-diamino-1,3,5-triazine derivatives as neuronal voltage-gated sodium channel blockers. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5644|[2]Yu Zhou, et al. Structure-Based Discovery of Novel and Selective 5-Hydroxytryptamine 2B Receptor Antagonists for the Treatment of Irritable Bowel Syndrome. J Med Chem. 2016 Jan 28;59(2):707-20.|[3]Huang Niu, et al. 5-HT2B Antagonists. WO2015158214
CAS Number
– 393129-91-4
Molecular Weight
– 296.17
Compound Purity
– 99.86
SMILES
– BrC1=CC=C(NC2=NC(N)=NC(C)(C)N2)C=C1
Clinical Information
– No Development Reported
Research Area
– Cancer; Endocrinology; Metabolic Disease; Cardiovascular Disease
Solubility
– DMSO : ≥ 33.33 mg/mL|H2O : 12.5 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– 5-HT Receptor
Isoform
– 5-HT2 Receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
