Download Files:
4E1rcat
Price range: 75 CAD through 590 CAD
Products Details
Product Description
– 4E1RCat is a dual inhibitor of eIF4E:eIF4 g and eIF4E:4E-BP1 interaction. And it inhibits the binding of eIF4 g to eIF4E with IC50 of 3.2 μM.
Web ID
– T1742
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C28H18N2O6
Citations
– 1. Chen C, Zhang X, Wang Y, et al. Translational and Post-translational Control of Human Naïve versus Primed Pluripotency. iScience. 2021: 103645.
2. Xiang H, Zhou M, Li Y, et al.Drug discovery by targeting the protein‒protein interactions involved in autophagy.Acta Pharmaceutica Sinica B.2023
3. Xiang H, Liu R, Zhang X, et al.Discovery of Small-Molecule Autophagy Inhibitors by Disrupting the Protein–Protein Interactions Involving Autophagy-Related 5.Journal of Medicinal Chemistry.2023
4. Zou C, Li W, Zhang Y, et al.Identification of an anaplastic subtype of prostate cancer amenable to therapies targeting SP1 or translation elongation.Science Advances.2024, 10(14): eadm7098.
References
– Shuda M, et al. Proc Natl Acad Sci U S A. 2015 May 12;112(19):5875-82.
CAS Number
– 328998-25-0
Molecular Weight
– C28H18N2O6
Compound Purity
– 0.9947
SMILES
– OC(=O)c1ccc(cc1)N1C(=O)C(=Cc2ccc(o2)-c2ccc(cc2)[N+]([O-])=O)C=C1c1ccccc1
Target
– Prostaglandin Receptor
Pathway
– Autophagy|||Apoptosis
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
Related Products
1000 in stock
1000 in stock
