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4E1RCat
$88 – $495
Products Details
Product Description
– 4E1RCat is an inhibitor of cap-dependent translation, and inhibits eIF4E:eIF4GI interaction, with an IC50 an of ∼4 μM.
Web ID
– HY-14427
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C28H18N2O6
References
– [1]Cencic R, et al. Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F. Proc Natl Acad Sci U S A. 2011 Jan 18;108(3):1046-51.|[2]Shuda M, et al. CDK1 substitutes for mTOR kinase to activate mitotic cap-dependent protein translation. Proc Natl Acad Sci U S A. 2015 May 12;112(19):5875-82.
CAS Number
– 328998-25-0
Molecular Weight
– 478.45
Compound Purity
– 99.10
SMILES
– O=C(O)C1=CC=C(N2C(/C(C=C2C3=CC=CC=C3)=CC4=CC=C(C5=CC=C([N+]([O-])=O)C=C5)O4)=O)C=C1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 18.33 mg/mL (ultrasonic)
Target
– Autophagy;Eukaryotic Initiation Factor (eIF)
Isoform
– eIF4
Pathway
– Autophagy;Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
