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Products Details
Product Description
– 4-Desmethoxy Omeprazole is the active metabolite of Omeprazole. Omeprazole, a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM[1]. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria[2].
Web ID
– HY-135111
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C16H17N3O2S
References
– [1]Li XQ, et al. Comparison of inhibitory effects of the proton pump-inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole on human cytochrome P450 activities. Drug Metab Dispos. 2004 Aug;32(8):821-7.|[2]Jonkers D, et al. Omeprazole inhibits growth of gram-positive and gram-negative bacteria including Helicobacter pylori in vitro. J Antimicrob Chemother. 1996 Jan;37(1):145-50.
CAS Number
– 110374-16-8
Molecular Weight
– 315.39
SMILES
– COC1=CC=C2N=C(S(CC3=NC=C(C)C=C3C)=O)NC2=C1
Clinical Information
– No Development Reported
Research Area
– Cancer; Infection; Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– Drug Metabolite
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
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