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Products Details
Product Description
– KRASG12C IN-15 (Compound 21) is an orally active KRASG12C inhibitor that effectively blocks SOS1-mediated GDP/GTP exchange with an IC50 of 19 nM. It inhibits ERK phosphorylation with an IC50 of 0.051 μM and reduces the viability of KRASG12C mutant MIA PaCa-2 cells with an IC50 of 0.023 μM. Additionally, KRASG12C IN-15 demonstrates antitumor activity in a MIA PaCa-2 xenograft mouse model.
Web ID
– T205541
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C31H32FN3O2
CAS Number
– 2768868-14-8
Molecular Weight
– C31H32FN3O2
SMILES
– FC=1C(=C2C([C@]3(C(C)(C)[C@@](C2)(C3)[H])[H])=NC1N4CC5(CC4)CN(C(C=C)=O)C5)C=6C7=C(C=C(O)C6)C=CC=C7
Pathway
– GPCR/G Protein|||MAPK
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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