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Taccalonolide A
Price range: 77 CAD through 264 CAD
For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.
Products Details
Product Description
– Taccalonolide A is the first microtubule stabilizing agent to be discovered from a plant since identification of the mechanism of action of paclitaxel and it is the first natural product steroid identified to have these cellular effects,with cytotoxic and antimalarial activities. Taccalonolide A causes G2-M accumulation, Bcl-2 phosphorylation and initiation of apoptosis. Taccalonolide A is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug resistance protein 7 (MRP7), with an IC50 of 622 nM for SK-OV-3 cells.
Web ID
– TN2254
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C36H46O14
References
– Li J , Risinger A L , Mooberry S L . Taccalonolide microtubule stabilizers[J]. Bioorganic & Medicinal Chemistry, 2014, 22(18):5091-5096.
CAS Number
– 108885-68-3
Molecular Weight
– C36H46O14
Compound Purity
– 0.994
SMILES
– [H][C@@]12[C@H](OC(C)=O)[C@@]3([H])[C@]4([H])[C@@H](O)C(=O)[C@@]5([H])C[C@@H]6O[C@@H]6[C@H](OC(C)=O)[C@]5(C)[C@@]4([H])[C@H](OC(C)=O)[C@H](OC(C)=O)[C@]3(C)[C@@]1([H])[C@H](C)C=C1OC(=O)[C@@](C)(O)[C@]21C
Pathway
– Cytoskeletal Signaling|||Apoptosis
Product type
– Natural Product
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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